2023 SPARK
GLOBAL TRANSLATIONAL RESEARCH BOOTCAMP & CONFERENCE

Introduction

SPARK Taiwan 計畫主要是配合生醫產業發展推動,提供欲投入藥物或醫療器材產品開發,或已有研發成果但缺乏商品化概念的團隊全方面的育成與產業化輔導,並於初期提供早期投資經費協助其產品開發計劃的發展。在過去的十年期間,SPARK Taiwan計畫透過與六所區域大學的合作,包含國立臺灣大學、國立成功大學、台北醫學大學、高雄醫學大學、長庚大學與輔仁大學,截至2023年共輔導了52家新創公司的成立、培育了480個以上的生技醫療相關創業團隊。且超過3,000人次以上參與過SPARK Taiwan的相關課程活動。

The SPARK Program is dedicated to helping academic innovation transition into commercialization. SPARK T aiwan, over the past 10 years, has successfully spun off 52 companies, and executing around 480 biomedical innovation projects. Over 3,000 individuals from universities, research institution, medical centers have participated in this program to translate their research outcomes into products, fostering future teams for industry entry.

Translational Research Bootcamp

Here the Stanford SPARK team will lead participants through the SPARK methodology in an interactive workshop to give them the foundation to discover, develop and deliver new treatments for unmet medical needs. The focus will be on working through real-life problems and solutions.

Global SPARK Meeting

Every year the SPARK Global programs from over 20 countries gather to build collaborations and share our successes and challenges. Importantly we take this opportunity to work together to improve the Global SPARK program.

SPARK Taiwan Asia Showcase

We will share featured programs from SPARK Taiwan with you and present partnering opportunities.

2023 SPARK TAIWAN BOOTCAMP AGENDA

Time July 24 Time July 25 Time July 26
09:00-09:20
Welcome & Program Overview
Emcee, Yu-Feng Jane Tseng, PhDProgram Overview: Kevin Grimes, MD, MBA
09:00-10:10 Agenda Overview 09:00-09:30 Agenda Overview
09:20-10:30 Starting with the End in Mind
Clinical Need Assessment & Target Product Profile Development
Kevin Grimes, MD, MBA
60 min Lecture, 10 min Q&A
10:10-10:40 Developing a Treatment-
Chronic Ear Drum Perforations
Case study in Product Development

Peter Santa Maria, PhD
20 min Lecture, 10 min Q&A
09:30-10:00 TPP Working Groups
Group Leaders - Kevin Grimes, MD;
Peter Santa Maria, MD, PhD;
Dirk Mendel, PhD
10:30-11:00
Understanding the Problem
Chronic Ear Drum PerforationsCase Study in Product Discovery
Peter Santa Maria, MD, PhD
20 min Lecture, 10 min Q&A
10:40-10:50
Coffee Break


10:00-12:00
TPP Pitches
10 min presentations, 10 min Q&A

11:00-11:10 Coffee Break 10:50-12:00 Target Validation /Pharmacology
Dirk Mendel, PhD

60 min Lecture, 10 min Q&A
11:10-12:20 Translating a Therapeutic Discovery
Dirk Mendel, PhD
60 min Lecture, 10 min Q&A
12:00-13:00
Delivering an Effective Pitch
to Potential Investors
Lunch & Learn
Peter Santa Maria, MD, PhD

30 min Lecture, 10 min Q&Q
12:20-13:20 Developing Your Target Product Profile(TPP)
Lunch & Initial Project Discussions
13:00-14:10
Clinical Trial Design
Kevin Grimes, MD, MBA
60 min Lecture, 10 min Q&A
13:20-15:05 A Design Thinking Approach to
Translational Medicine
Peter Santa Maria, MD, Ph.D
30 min Lecture, 1 hr 15 min Workshop
14:10-15:10
TPP Working Groups
Group Leaders - Kevin Grime, MD;
Peter Santa Maria, PhD;
Dirk Mendel, PhD
15:05-15:25 Coffee & Refreshment Break
15:10-15:30
Coffee & Refreshment Break
15:25-17:50 TPP Working Groups
Group Leaders - Kevin Grimes, MD;
Peter Santa Maria, MD, PhD;
Dirk Mendel, PhD
15:30-17:50
TPP Working Groups
Group Leaders - Kevin Grimes, MD;
Peter Santa Maria, MD, PhD;
Dirk Mendel, PhD
18:00-20:00 Reception Dinner

2023 GLOBAL SPARK MEETING AGENDA

July 26 (Day 1)
13:30-14:00
Welcome Introduction & Program Overview : Yufeng Jane Tseng, PhD, Director SPARK TAIWAN
Opening Remarks : Deputy Minister Yi-Juang Chern, National Science and Technology Council
14:00-14:30
SPARK GLOBAL:Where Are We & Where Are We Going? : Peter Santa Maria, MD, PhD, SPARK TAIWAN
14:30-15:00 SPARK TAIWAN:Ten Years of SPARKing : Yufeng Jane Tseng, PhD, Director SPARK TAIWAN
15:00-15:30 Coffee & Refreshment Break
15:30-17:00 SPARK GLOBAL Updates : SPARK Program Directors
17:00-20:00 Reception Dinner
July 27 (Day 2)
09:00-09:10 Wednesday Recap & Thursday Agenda : Yufeng Jane Tseng, PhD
09:10-11:10 Competitiveness of Taiwan’s Clinical Trial Medical Regulations : Dr. Hen Dern Chen, MD, PhD,
Genomics Research Center, Academic Sinica
New Drugs Regulatory Strategies and Guidance : Dr. Sherry Ku, Chairman, Good Group Consultation Corporation Important Trends and Challenges in the Adoption of Smart Technology in Clinical Decision-making Regulations : Dr. Chih-Hsiung Chen, Dean & Professor, National Yang Ming Chiao Tung University
Round Table Discussion
Concluding Remarks
11:10-12:10 From the Benchside to Patient Care - Case Study : Peter Santa Maria, MD, PhD
12:10-13:00 Lunch
13:00-14:00 From the Benchside to Patient Care - Case Study : Dirk Mendel, PhD
14:00-15:30 SPARK GLOBAL Updates & Working Together Workshop :
Updates by SPARK Program Directors and Working Together Moderated by Peter Santa Maria, MD, PhD
15:30-16:00 Coffee & Refreshment Break
16:00-18:00 SPARK GLOBAL Updates & Working Together Workshop :
Updates by SPARK Program Directors and Working Together Moderated by Peter Santa Maria, MD, PhD
18:00-20:00 Night Market Tour (Optional)
Location : Raohe Street Night Market (饒河夜市)
July 28 (Day 3)
09:00-09:10 Thursday Recap & Friday Agenda : Dr. Yufeng Jane Tseng, PhD, Director of SPARK Taiwan Office
09:10-10:00 Panel Bioventure & Commercialization in Japan Market Innovation and Advamces in Biotechnology : Implications for the Japanese Market (20min) : Dr. Shin Kawamata, MD, Ph.D., CEO of Cyto-Facto, Director, Research and Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation Market Access and Commercialization Strategies for Biotech Products in Japan (20min) :
Dr. Ken-Ichiro Kosai, MD., Ph.D., Kagoshima University
Q&A Concluding Remarks : Dr. Yufeng Jane Tseng, PhD, Director of SPARK Taiwan Office
10:10-11:10 Panel : Bioventure & Commercialization in Asia Introduction : Dr. Jane Tsai, Vice President, YFY Biotech Management Dr. Berry Murphy, CRO, NOVOTECH
Round Table Discussion : Dr. Jane Tsai, Vice President, YFY Biotech Management ; Dr. Berry Murphy, CRO, NOVOTECH Dr. Michel Chu, Ph.D., President, Industrial Technology Investment Corporation.
Dr. Ken-Ichiro Kosai, MD, Ph.D., Kagoshima Universit ; Dr. Reshman Ganapathi, Ph.D., Senior Scientific Advisor, NOVOTECH Concluding Remarks : Yufeng Jane Tseng, PhD
11:10-12:10 Concluding Remarks : Peter Santa Maria, MD, PhD and Yufeng Jane Tseng, PhD

2023 SPARK TAIWAN ASIA SHOWCASE AGENDA

Time July 28
13:00 - 13:10 Opening Remarks
Welcome from SPARK Global,Professor Peter Santa Maria
Welcome from SPARK Taiwan, Professor Yufeng Jane Tseng
13:10 - 13:25 National Taiwan University, SPARK Taiwan
GLUT Targeting Small Molecule Dug Conjugation for Cancer
Therapy Speaker: Pi-Huang Liang
13:25 - 13:40 Taipei Medical University, SPARK Taiwan
Cancer Stem Cell Isolation Platform for Drug Discovery
Speaker: Yao-An Shen
13:40 - 13:55 Kaohsiung Medical University, SPARK Taiwan
Disease-directed Antibody Lock: Improve patients’ life quality by enhancing the safety and efficacy of antibody
Speaker: Yun-Chi Lu, CEO & Co-founder
13:55 - 14:10 University of Colorado, SPARK Colorado
Rock Immune CCR4-IL2 Bispecific Immunotoxin for Targeted T herapy of Cutaneous T-Cell Lymphoma and Other Cancers
Speaker: Zhirui Wang, DVM
14:10 - 14:25 National Taiwan University, SPARK Taiwan
Novel Therapeutic Agents for Abdominal Pain in Irritable Bowel Syndrome
Speaker: Ling-Wei Hsin
14:25 - 14:40 FuJen University, SPARK Taiwan
CytoSCM: Living Single Cells Microfluidic Capture Microdissection
Speaker: Rex Wu, Founder CEO & CTO
14:40 – 15:10 Refreshment Break & Coffee
15:10 - 15:25 Kaohsiung Medical University, SPARK Taiwan
3D Printable Bone Graft Substitute
Speaker: Lily-Lin, CIO / Promotions
15:25 - 15:40 University of Colorado, SPARK Colorado
The “Button Huggie” A Securement Device for Gastrostomy and Cecostomy Buttons
Speaker : Steve Moulton
15:40 - 15:55 National Cheng Kung University, SPARK Taiwan
aiFREE Intelligent Health Partner
Speaker: Y. C. Lin
15:55 - 16:10 National Taipei Medical University, SPARK Taiwan
Preclinical AI drug discovery and development platform
Speaker: Sung Ting Yi
16:10 - 16:25 Osaka University, SPARK Japan
Development of Electrophysiological Determination of Uterine Receptivity (EDUR)
Speaker: Hitomi Nakamura
16:25 - 17:30 Networking
17:30 - 17:40 Concluding Remarks
18:00 - 20:00 Reception Dinner (Invitation Only)
 

Speakers

Prof. Daria Mochly-Rosen

Founder and Director of SPARK At Stanford,
Professor of Chemical and Systems Biology, Stanford University School of Medicine

Professor Daria Mochly-Rosen helps academics navigate the so-called “valley of death” between drug discovery and development. Professor Mochly-Rosen founded The SPARK Program at Stanford in 2006 after having to leave academia to start a pharmaceutical company to translate her protein kinase C research into cardiovascular therapeutics. Challenging the academic dogma of how scientific discoveries should reach the pharmaceutical industry, the SPARK model has been implemented internationally and has resulted in a book about drug development from academia. Professor of Chemical and Systems Biology at Stanford, she leads a multi-disciplinary research lab that includes chemists, biochemists, biologists and physician scientists. She has published over 285 papers and over 36 patents and patent applications. Professor Mochly-Rosen is originally from Israel, where she received her doctorate in Chemical Immunology from The Weizmann Institute of Science.

Dr. Michael Ackermann

Director of Biotechnology for the Stanford
University Byers Center for Biodesign,.
Co-founder and Chairman of Tarsus Pharmaceuticals

Michael is Director of Biotechnology for the Stanford University Byers Center for Biodesign. He is also co-founder and serves as Chairman of the Board of Tarsus Pharmaceuticals (NASDAQ: TARS).   Michael is also co-founder, former CEO, and serves on the board of Presidio Medical.  Previously, he was co-founder and served as Chairman of Oyster Point Pharma, Inc. (NASDAQ: OYST). Prior to this, he was Vice President, Neurostimulation for Allergan (an AbbVie company), after serving as co-founder and CEO of Oculeve, Inc., which was acquired by Allergan, plc.  Michael received a BE degree from Vanderbilt University and MS and PhD degrees from Case Western Reserve University. He is a graduate of the Stanford University Biodesign Fellowship and Vision Research Fellowship.  He has more than 50 issued US patents and numerous patent applications and peer-reviewed publications.

Prof. Kevin Grimes

Co-Director of SPARK At Stanford
Professor of Chemical and Systems Biology,
Stanford University School of Medicine

Kevin Grimes, MD is Professor of Chemical and Systems Biology and Co-director of the SPARK Program at Stanford. While a Clinical Assistant Professor of Medicine at Stanford, he obtained an MBA at the Stanford Graduate School of Business. He was selected as a White House Fellow and served as Special Assistant to the Secretary of Defense. After 15 years in the biotech industry, he returned to Stanford. SPARK’s mission is to advance promising discoveries to patient care; to educate faculty and trainees regarding the translational process; and to identify more efficient approaches to bring new therapies to patients. The SPARK methodology has been adopted by over 50 academic institutions world-wide. Grimes teaches graduate student courses on drug discovery and development and continues to teach and practice internal medicine. He received the David Rytand Award for Excellence in Clinical Teaching and the Faculty Award for Excellence in Graduate Teaching.

Dr. Jeewon Kim

Program manager of SPARK At Stanford

Jeewon Kim received her undergraduate degree at Seoul National University in Korea and worked at Daesang Ltd, a Food and Drug company in Korea. She did her doctoral work at UC Berkeley in the lab of Dr. Marc Hellerstein, where she developed a stable isotope biomarker to detect early phases of colon cancer. She subsequently worked as a consultant for startup company Kinemed Inc. Then as a postdoctoral fellow, she began drug development work in Dr. Daria Mochly-Rosen’s lab at Stanford, studying the roles of different protein kinase C (PKC) isozymes in breast and prostate cancer. While in Dr. Mochly-Rosen’s lab, she worked to develop small peptides as anticancer drugs. This work has resulted in multiple publications and review papers and identified the roles of PKCs in cancer proliferation, angiogenesis, migration and metastasis. She then worked at the Stanford Cancer Institute Transgenic, Knockout and Tumor model Center (TKTC) as a group lead and preclinical oncology facility manager. She is currently a program manager and associate director of business development at SPARK since 2019.

 

SPARK Taiwan 計畫辦公室

洪萱芳 專案經理 | 02-2737-7173 | sparktw@narlabs.org.tw

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